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1551459-37-0

1551459-37-0 Structure

1551459-37-0 Structure
IdentificationBack Directory
[Name]

Carbamic acid, N-[(3R,7S)-7-[4-(3-chloro-2,6-difluorophenyl)-5,6-dihydro-2-oxo-1(2H)-pyridinyl]-2,3,4,5,6,7-hexahydro-3-methyl-2-oxo-1H-8,12-metheno-1,9-benzodiazacyclotetradecin-15-yl]-, methyl ester
[CAS]

1551459-37-0
[Synonyms]

Carbamic acid, N-[(3R,7S)-7-[4-(3-chloro-2,6-difluorophenyl)-5,6-dihydro-2-oxo-1(2H)-pyridinyl]-2,3,4,5,6,7-hexahydro-3-methyl-2-oxo-1H-8,12-metheno-1,9-benzodiazacyclotetradecin-15-yl]-, methyl ester
[Molecular Formula]

C31H29ClF2N4O4
[MOL File]

1551459-37-0.mol
[Molecular Weight]

595.04
Chemical PropertiesBack Directory
[Boiling point ]

782.2±60.0 °C(Predicted)
[density ]

1.341±0.06 g/cm3(Predicted)
[pka]

12.99±0.60(Predicted)
Hazard InformationBack Directory
[Description]

FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species
[Uses]

FXIa-IN-6 is a potent FXIa inhibitor with selectivity against most of the relevant serine proteases (Ki = 0.3 nM).
[References]

[1] Yang W, et al. Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species. J Med Chem. 2020 Jul 9;63(13):7226-7242. DOI:10.1021/acs.jmedchem.0c00464
1551459-37-0 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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