| Identification | Back Directory | [Name]
N-[1-[(1S)-3-(dimethylamino)-1-phenylpropyl]pyrazol-4-yl]-6,6-dimethyl-1,4,5,7-tetrahydroindazole-3-carboxamide | [CAS]
1557232-32-2 | [Synonyms]
GNE-9822
N-[1-[(1S)-3-(dimethylamino)-1-phenylpropyl]pyrazol-4-yl]-6,6-dimethyl-1,4,5,7-tetrahydroindazole-3-carboxamide
1H-Indazole-3-carboxamide, N-[1-[(1S)-3-(dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl]-4,5,6,7-tetrahydro-6,6-dimethyl- | [Molecular Formula]
C24H32N6O | [MDL Number]
MFCD28386193 | [MOL File]
1557232-32-2.mol | [Molecular Weight]
420.55 |
| Hazard Information | Back Directory | [Description]
GNE-9822 is a potent and selective ITK inhibitor. GNE-9822 shows good ADME properties in preclinical species. Interleukin-2 inducible T-cell kinase (ITK), a member of the Tec family of tyrosine kinases, plays a major role in T-cell signaling downstream of the T-cell receptor (TCR), and considerable efforts have been directed toward discovery of ITK-selective inhibitors as potential treatments of inflammatory disorders such as asthma. |
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