| Identification | Back Directory | [Name]
S-2E | [CAS]
155730-92-0 | [Synonyms]
S-2E >=98% (HPLC), powder
Benzoic acid, 4-[[(3S)-1-[4-(1,1-dimethylethyl)phenyl]-5-oxo-3-pyrrolidinyl]methoxy]- | [Molecular Formula]
C22H25NO4 | [MDL Number]
MFCD06407742 | [MOL File]
155730-92-0.mol | [Molecular Weight]
367.44 |
| Chemical Properties | Back Directory | [Boiling point ]
599.1±30.0 °C(Predicted) | [density ]
1.188±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 11 mg/mL | [form ]
powder | [pka]
4.43±0.10(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
S-2E may be used in cell signaling studies. | [Biochem/physiol Actions]
HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. In the liver, S-2E is converted into its active metabolite, S-2E-CoA. S-2E-CoA noncompetitively inhibited the enzymatic activities of both 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase and acetyl-CoA carboxylase at K(i)=18.11 microM and K(i)=69.2 microM, respectively. | [in vivo]
In the liver, S-2E is converted into its active metabolite, S-2E-CoA. S-2E-CoA noncompetitively inhibits the enzymatic activities of both 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase and acetyl-CoA carboxylase at Ki=18.11 μM and Ki=69.2 μM, respectively[1].
S-2E (3-30 mg/kg) given orally suppresses the secretion rate of very-low-density lipoprotein (VLDL)-cholesterol and triglyceride in Triton WR-1339-injected rats. Furthermore, S-2E lowers the blood total cholesterol and triglyceride levels simultaneously in Zucker fatty rats[1]. | [storage]
Store at -20°C |
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