| Identification | Back Directory | [Name]
N-Methylcarbonyl-2-chloroacetamidrazone | [CAS]
155742-64-6 | [Synonyms]
Aprepitant Stage-III (Impurity-D)
N-Methylcarbonyl-2-chloroacetamidrazone
N-carboMethoxy-2-chloroacetaMidohydrazone
(Z)-Methyl 2-(1-aMino-2-chloroethylidene)
N-(methoxycarbonyl)-2-chloroacetamidrazone
Methyl (Z)-2-chloro-1-hydrazino ethylidenecarbamate
Methyl 2-(2-chloro-1-iMinoethyl)hydrazinecarboxylate
2-(2-Chloro-1-iminoethyl)hydrazinecarboxylic Acid Methyl Ester
N'-(2-Chloro-1-iMino-ethyl)-hydrazinecarboxylic acid Methyl ester
Hydrazinecarboxylicacid, 2-(2-chloro-1-iMinoethyl)-, Methyl ester
N-Methylcarbonyl-2-chloroacetamidrazone 2-(2-Chloro-1-iminoethyl)hydrazinecarboxylic acid methyl ester | [EINECS(EC#)]
216-849-7 | [Molecular Formula]
C4H8ClN3O2 | [MDL Number]
MFCD09840880 | [MOL File]
155742-64-6.mol | [Molecular Weight]
165.58 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
>125°C (dec.) | [density ]
1.43 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
7.62±0.43(Predicted) | [color ]
Pale Beige to Light Beige | [InChI]
InChI=1S/C4H8ClN3O2/c1-10-4(9)8-7-3(6)2-5/h2H2,1H3,(H2,6,7)(H,8,9) | [InChIKey]
JAIGTTPBXVVFPN-UHFFFAOYSA-N | [SMILES]
N(C(OC)=O)NC(=N)CCl |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
N-Methylcarbonyl-2-chloroacetamidrazone is useful for preparing the intermediate of Fosaprepitant. | [Synthesis]
Nitrogen protection in 1000ml three-necked flask was added chloroacetonitrile 50g (0.67mol), 200ml methanol sequentially and cooled to 0℃. Dissolve 1g of sodium methanol in 50ml of methanol and add it to the reaction vial dropwise. After dropwise addit |
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