| Identification | Back Directory | [Name]
4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-3-(1-methylpropyl)-2-thioxo-, (5Z)- | [CAS]
1558598-48-3 | [Synonyms]
PFM03
4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-3-(1-methylpropyl)-2-thioxo-, (5Z)- | [Molecular Formula]
C14H15NO2S2 | [MOL File]
1558598-48-3.mol | [Molecular Weight]
293.4 |
| Chemical Properties | Back Directory | [Boiling point ]
434.9±55.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
8.59±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
PFM03 is a MRE11 Endonuclease inhibitor. PFM03 regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ)[1]. | [References]
[1] Shibata A, et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53(1):7-18. DOI:10.1016/j.molcel.2013.11.003 |
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