| Identification | Back Directory | [Name]
GPRP (acetate) | [CAS]
157009-81-9 | [Synonyms]
Pefa 6003
Pefabloc FG)
GPRP (acetate)
GPRP ACETATE, >98%
H-Gly-Pro-Arg-Pro-OH (acetate)
GLY-PRO-ARG-PRO ACETATE;PEFABLOC FG
GPRP acetate
(Gly-Pro-Arg-Pro acetate
GPRP acetate,Gly-Pro-Arg-Pro acetate,Glycyl-L-prolyl-L-arginyl-L-proline acetate,Pefa 6003,Pefabloc FG, >98% | [Molecular Formula]
C20H35N7O7 | [MDL Number]
MFCD00133378 | [MOL File]
157009-81-9.mol | [Molecular Weight]
485.54 |
| Hazard Information | Back Directory | [Uses]
GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa)[1][2][3]. | [in vivo]
GPRP acetate (100 mg/kg; i.p., once daily for 10 days) significantly alleviates DSS-induced colitis through the improvement of body weight loss and mortality[3]. | Animal Model: | C57BL/6 mice with dextran sulphate sodium (DSS)-induced colitis[3] | | Dosage: | 100 mg/kg | | Administration: | Intraperitoneal injection; 100 mg/kg, once daily, for 10 days | | Result: | Significantly inhibited body weight loss and reduced DSS-induced mortality and shortening of colon length, and decreased tissue damage and infiltration of inflammatory cells in colitis mice. Decreased levels of inflammatory cytokines in colitis mice.
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| [References]
[1] Gallistl S, et al. Gly-pro-arg-pro (GPRP) enhances free thrombin. Thromb Res. 1995 Jun 15;78(6):547-50. DOI:10.1016/0049-3848(95)e0088-8
[2] Hsieh KH, et, al. Fibrin Polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization. J Med Chem. 1981 Mar; 24(3): 322-7. DOI:10.1021/jm00135a016
[3] Zhang C, et al. Fibrinogen/AKT/Microfilament Axis Promotes Colitis by Enhancing Vascular Permeability. Cell Mol Gastroenterol Hepatol. 2021;11(3):683-696. DOI:10.1016/j.jcmgh.2020.10.007 |
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