| Identification | Back Directory | [Name]
benzomalvin B | [CAS]
157047-97-7 | [Synonyms]
benzomalvin B
Quinazolino[3,2-a][1,4]benzodiazepine-5,13-dione, 6,7-dihydro-6-methyl-7-(phenylmethylene)-, (7E)-(+)- (9CI) | [Molecular Formula]
C24H17N3O2 | [MDL Number]
MFCD33021144 | [MOL File]
157047-97-7.mol | [Molecular Weight]
379.41 |
| Chemical Properties | Back Directory | [Boiling point ]
612.1±65.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
A solid | [pka]
-2.03±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
Benzomalvin B is a fungal metabolite originally isolated from Penicillium. It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P by 24% in vitro when used at a concentration of 100 μg/ml. | [Uses]
Benzomalvin B is the less active analogs of Benzomalvin A. Benzomalvin B is weakly active against substance P[1]. | [storage]
Store at -20°C | [References]
[1] Sun HH, et al. Benzomalvins, new substance P inhibitors from a Penicillium sp. J Antibiot (Tokyo). 1994;47(5):515-522. DOI:10.7164/antibiotics.47.515 |
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