| Identification | Back Directory | [Name]
AB-423 | [CAS]
1572510-80-5 | [Synonyms]
AB-423
CS-2686
AB423;AB-423;AB 423
N-(3,4-Difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]benzamide
Benzamide, N-(3,4-difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]- | [Molecular Formula]
C17H17F3N2O3S | [MDL Number]
MFCD31657418 | [MOL File]
1572510-80-5.mol | [Molecular Weight]
386.39 |
| Chemical Properties | Back Directory | [density ]
1.372±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:88.5(Max Conc. mg/mL);229.04(Max Conc. mM)
Ethanol:77.0(Max Conc. mg/mL);199.28(Max Conc. mM) | [form ]
Solid | [pka]
10.84±0.70(Predicted) | [color ]
White to off-white | [CAS DataBase Reference]
1572510-80-5 |
| Hazard Information | Back Directory | [Uses]
N-(3,4-Difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]benzamide, is an inhibitor of HBV capsid assembly. AB-423 shows inhibitory effect on rcDNA production in AML12-HBV10 and HepDE19 cells with EC50s of ～0.260 μM | [in vivo]
AB-423 (30 and 100 mg/kg, p.o. bid) blocks HBV replication in a mouse model of HBV. AB-423 (100 mg/kg, p.o. bid) with entecavir (ETV, 100 ng/mg, qd, p.o.) or 0.1 mg/kg dose of ARB-1467 potently inhibits serum HBV DNA in an HDI model of HBV in immunodeficient NOD-SCID mice[1]. | [storage]
Store at -20°C |
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| Company Name: |
Twochem Co.Ltd.
|
| Telephone: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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