| Identification | Back Directory | [Name]
4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate | [CAS]
1577222-14-0 | [Synonyms]
ALKS-8700
diroximel fumarate
Diroximel Fumarete
Diroximel Fumarete(ALKS-8700)
5-dioxopyrrolidin-1-yl)ethyl methyl fumarate
2-(2,5-Dioxopyrrolidin-1-yl)ethyl methyl fumarate
2-(2,5-Dioxopyrrolidin-1-Yl)Ethyl Methyl Fumarate(WXC04774)
4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate
(2E)-2-Butenedioic acid 1-[2-(2,5-dioxo-1-pyrrolidinyl)ethyl] 4-methyl ester
(E)-but-2-enedioic acid 2-(2,5-dioxo-pyrrolidin-1-yl)ethyl ester methyl ester
2-Butenedioic acid (2E)-, 1-[2-(2,5-dioxo-1-pyrrolidinyl)ethyl] 4-methyl ester
DIROXIMEL FUMARATE; ALKS8700; ALKS 8700; ALKS-8700;2-(2;5-DIOXOPYRROLIDIN-1-YL)ETHYL METHYL FUMARATE | [Molecular Formula]
C11H13NO6 | [MDL Number]
MFCD28502263 | [MOL File]
1577222-14-0.mol | [Molecular Weight]
255.22 |
| Chemical Properties | Back Directory | [Melting point ]
96 - 99°C | [Boiling point ]
441.0±25.0 °C(Predicted) | [density ]
1.319±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Ethyl Acetate (Slightly) | [form ]
Solid | [pka]
-1.60±0.20(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C11H13NO6/c1-17-10(15)4-5-11(16)18-7-6-12-8(13)2-3-9(12)14/h4-5H,2-3,6-7H2,1H3/b5-4+ | [InChIKey]
YIMYDTCOUQIDMT-SNAWJCMRSA-N | [SMILES]
C(OCCN1C(=O)CCC1=O)(=O)/C=C/C(OC)=O |
| Hazard Information | Back Directory | [Description]
Diroximel fumarate is a prodrug form of monomethyl fumarate (Item No. 27813).1 It undergoes esterase cleavage in the gut to release monomethyl fumarate. Formulations containing diroximel fumarate have been used in the treatment of relapsing-remitting multiple sclerosis. | [Uses]
Diroximel Fumarate is a novel oral fumarate in development for the treatment of patients with relapsing forms of multiple sclerosis. | [in vivo]
Diroximel fumarate (60-100 mg/kg , p.o., daily, 5 days) prevents MGO-induced mechanical and cold hypersensitivity in male and female wild-type C57BL/6 mice[2].
| [storage]
Store at -20°C | [References]
[1] R. NAISMITH. Diroximel fumarate (DRF) in patients with relapsing–remitting multiple sclerosis: Interim safety and efficacy results from the phase 3 EVOLVE-MS-1 study[J]. Multiple Sclerosis Journal, 2019, 115 1: 1729-1739. DOI: 10.1177/1352458519881761 |
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Wuxi AppTec
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022-59987777 13552403979 |
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Twochem Co.Ltd.
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cn.twochem.com |
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