| Hazard Information | Back Directory | [Uses]
Mcl-1 inhibitor 10 (compound 43) is a relatively strong MCL-1 inhibitor (IC50=0.67 μM). Mcl-1 inhibitor 10 interacts with specific binding sites of MCL-1 protein to block the pro-survival signal of MCL-1 and push cancer cells into apoptosis. Mcl-1 inhibitor 10 can be used in the study of MCL-1 dependent cancers[1]. | [References]
[1] Petros A M, et al. Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein[J]. Bioorganic & medicinal chemistry letters, 2014, 24(6): 1484-1488. DOI:10.1016/j.bmcl.2014.02.010 |
|
|