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1584713-87-0

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1584713-87-0 Structure

1584713-87-0 Structure
IdentificationBack Directory
[Name]

BMS-983970
[CAS]

1584713-87-0
[Synonyms]

BMS-983970
BMS983970,BMS 983970
Butanediamide, 3-(cyclopropylmethyl)-N1-[(3S)-9-fluoro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-2-(3,3,3-trifluoropropyl)-, (2R,3S)-
[Molecular Formula]

C26H26F4N4O3
[MDL Number]

MFCD28385842
[MOL File]

1584713-87-0.mol
[Molecular Weight]

518.5
Chemical PropertiesBack Directory
[Boiling point ]

730.2±60.0 °C(Predicted)
[density ]

1.45±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: ≥ 50 mg/mL (96.43 mM); Water: < 0.1 mg/mL (insoluble)
[form ]

Powder
[pka]

10.57±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

BMS-983970 is an oral pan-Notch inhibitor for the treatment of multiplecancers[1].
[in vivo]

BMS-983970 demonstrates anti-tumor activity in T-cell acute lymphoblastic leukemia (T-ALL) and solid tumor xenograft models[1].

[References]

[1] Ashvinikumar V. Gavai, et al. Abstract 1643: BMS-983970, an oral pan-Notch inhibitor for the treatment of cancer. Cancer Res October 1, 2014 74; 1643.
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