| Identification | Back Directory | [Name]
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE | [CAS]
159190-45-1 | [Synonyms]
L-NIL HCL
L-NIL DIHYDROCHLORIDE
L-N6-(1-Iminoethyl)lysine
OQIBCXRAFAHXMM-KLXURFKVSA-N
L-N6-(1-IMINOETHYL)-LYSINE 2HCL
L-N6-(1-IMINOETHYL)LYSINE, DIHCL
L-Lysine ω-acetamidine dihydrochloride
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE
L-Lysine, N6-(1-iMinoethyl)-, (Hydrochloride) (1:2) | [Molecular Formula]
C8H19Cl2N3O2 | [MDL Number]
MFCD00270890 | [MOL File]
159190-45-1.mol | [Molecular Weight]
260.16 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml | [form ]
White to off-white solid. | [biological source]
synthetic (organic) | [Water Solubility ]
water: 50mg/mL, clear, colorless |
| Hazard Information | Back Directory | [Description]
L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 μM for iNOS as opposed to 8-38 and 17-92 μM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major. | [Uses]
L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:
- to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine
- to study its effects on leptin-induced inflammation in hepatocytes
- to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)
| [Definition]
ChEBI: N(6)-acetimidoyl-L-lysine dihydrochloride is a hydrochloride salt prepared from N(6)-acetimidoyl-L-lysine and two equivalents of hydrogen chloride. A selective inhibitor of inducible nitric oxide synthase. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It contains a N(6)-acetimidoyl-L-lysinium(2+). | [Biochem/physiol Actions]
Selective inhibitor of inducible nitric oxide synthase (iNOS). | [in vivo]
L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice[1]. | Animal Model: | Adult male Balb/c (20-25 g)[1]. | | Dosage: | 10 and 30?mg/kg. | | Administration: | Intraperitoneally at the end of CLP and at 6?h after sepsis induction. | | Result: | Led to a negligible increase in plasma NGAL compared to sham mice.
Led to a significant decrease in both TLR4 and IL1β?protein contents and clusterin transcript.
Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.
Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
|
| [IC 50]
iNOS |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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