| Identification | Back Directory | [Name]
Iodoacetamide-PEG3-azide | [CAS]
1594986-04-5 | [Synonyms]
Iodoacetamide-PEG3-azide
Azido-PEG3-iodoacetamide | [Molecular Formula]
C10H19IN4O4 | [MDL Number]
MFCD30469120 | [MOL File]
1594986-04-5.mol | [Molecular Weight]
386.19 |
| Hazard Information | Back Directory | [Uses]
Iodoacetamide-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Iodoacetamide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [Biological Activity]
Iodoacetamide-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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