| Identification | Back Directory | [Name]
O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 | [CAS]
846549-37-9 | [Synonyms]
N3-(PEG)7-COOH
azido-peg-acid (n=8)
N-(PEG)-COOH (33 atoms)
N3-(PEG)7-COOH (33 ATOMS) 1 G
N3-PEG8-CH2CH2NHCOCH2OCH2COOH
N-(PEG)-COOH (33 atoms) Novabiochem
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7
O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7
O-(2-Azidoethyl)-O-[2-(diglycoly-amino)ethyl]heptaethylene glycol
O-(2-Azidoethyl)-O-[2-(diglycolyl-aMino)ethyl]heptaethylene glycol >=90% (oligoMer purity)
2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethoxy]acetic acid | [Molecular Formula]
C22H42N4O12 | [MDL Number]
MFCD03453234 | [MOL File]
846549-37-9.mol | [Molecular Weight]
554.59 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at +2°C to +8°C. | [form ]
Liquid | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C22H42N4O12/c23-26-25-2-4-31-6-8-33-10-12-35-14-16-37-18-17-36-15-13-34-11-9-32-7-5-30-3-1-24-21(27)19-38-20-22(28)29/h1-20H2,(H,24,27)(H,28,29) | [InChIKey]
WWDNBBVPYDZICO-UHFFFAOYSA-N | [SMILES]
C(CNC(=O)COCC(=O)O)OCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] |
| Hazard Information | Back Directory | [Description]
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG linker containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [reaction suitability]
reaction type: click chemistry
reagent type: cross-linking reagent | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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