| Identification | Back Directory | [Name]
(p-Iodo-Phe)-ACTH (4-10) | [CAS]
159600-82-5 | [Synonyms]
(p-Iodo-Phe)-ACTH (4-10) | [Molecular Formula]
C44H58IN13O10S | [MDL Number]
MFCD00798699 | [MOL File]
159600-82-5.mol | [Molecular Weight]
1087.98 |
| Hazard Information | Back Directory | [Uses]
(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats[1]. | [in vivo]
(p-Iodo-Phe7)-ACTH (4-10) (15 μg per animal; i.c.v.; single dose) blocks the a-MSH-induced excessive grooming behavior in rats[1].
| Animal Model: | Male Wistar rats (150 g)[1] | | Dosage: | 1.5 or 15 μg per animal, mixed with 1.5 μg α-MSH or not | | Administration: | Intracerebroventricular injection; one week prior to the experiment | | Result: | Didn’t induce excessive grooming behavior by single dose.
Inhibited the induction of excessive grooming behavior by a-MSH. |
| [References]
[1] Adan RA, et al. Identification of antagonists for melanocortin MC3, MC4 and MC5 receptors. Eur J Pharmacol. 1994 Nov 15;269(3):331-7. DOI:10.1016/0922-4106(94)90041-8
[2] Schi?th HB, et al. Selectivity of [Phe-I7], [Ala6], and [D-Ala4,Gln5,Tyr6] substituted ACTH(4-10) analogues for the melanocortin receptors. Peptides. 1997;18(5):761-3. DOI:10.1016/s0196-9781(97)00126-5 |
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