| Identification | Back Directory | [Name]
2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid | [CAS]
1596348-16-1 | [Synonyms]
159141
KDM5 inhibitor C49
KDM-5-C49,KDM5 C49
KDM5-C49 hydrochloride
2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid
4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]- | [Molecular Formula]
C15H24N4O3 | [MDL Number]
MFCD31539980 | [MOL File]
1596348-16-1.mol | [Molecular Weight]
308.38 |
| Chemical Properties | Back Directory | [Boiling point ]
531.0±50.0 °C(Predicted) | [density ]
1.168±0.06 g/cm3(Predicted) | [form ]
Solid-Liquid Mixture | [pka]
3.16±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
KDM5-C49 (KDOAM-20) is a potent and selective inhibitor of KDM5 demethylases, with IC50s of 40 nM, 160 nM, and 100 nM for KDM5A, KDM5B, and KDM5C enzymes, respectively. KDM5-C49 can be used for the research of cancer[1]. | [IC 50]
KDM5 | [References]
[1] Horton JR, et, al. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol. 2016 Jul 21;23(7):769-781. DOI:10.1016/j.chembiol.2016.06.006
[2] Song YQ, et al. The role and prospect of lysine-specific demethylases in cancer chemoresistance. Med Res Rev. 2023 Apr 3. DOI:10.1002/med.21955 |
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