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1598426-03-9

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1598426-03-9 Structure

1598426-03-9 Structure
IdentificationBack Directory
[Name]

2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid ethyl ester
[CAS]

1598426-03-9
[Synonyms]

CG347B
CTTSUGRYXUPYIO-UHFFFAOYSA-N
2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid ethyl ester
5-Pyrimidinecarboxylic acid, 2-[(1-phenylcyclopropyl)amino]-, ethyl ester
[Molecular Formula]

C16H17N3O2
[MDL Number]

MFCD28347705
[MOL File]

1598426-03-9.mol
[Molecular Weight]

283.33
Chemical PropertiesBack Directory
[Boiling point ]

457.2±47.0 °C(Predicted)
[density ]

1.278±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 250 mg/mL (882.36 mM)
[form ]

Solid
[pka]

1.94±0.10(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

CG347B is a selective HDAC6 inhibitor, also involves in synthesis of other metalloenzyme inhibitors. HDAC6 inhibitors can be used for oncology, immunology, and neurology research[1][2].
[IC 50]

HDAC6
[References]

[1] Wang W, et al. Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer. Mol Cancer. 2020 Sep 2;19(1):134. DOI:10.1186/s12943-020-01256-9
[2] Christopher M. YATES. Metalloenzyme inhibitor compounds. WO2018165520A1.
[3] Cui J, et al. IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation. Cell Death Dis. 2021 May 18;12(6):501. DOI:10.1038/s41419-021-03769-7
Spectrum DetailBack Directory
[Spectrum Detail]

2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid ethyl ester(1598426-03-9)1HNMR
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