| Identification | Back Directory | [Name]
Butanoic acid, 2-[[(2S)-2-[[(2S,3S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylpentyl]oxy]-1-oxo-3-phenylpropyl]amino]-4-(methylsulfonyl)-, (2S)- | [CAS]
160141-08-2 | [Synonyms]
L739750
L-739750
L 739750
Butanoic acid, 2-[[(2S)-2-[[(2S,3S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylpentyl]oxy]-1-oxo-3-phenylpropyl]amino]-4-(methylsulfonyl)-, (2S)- | [Molecular Formula]
C23H39N3O6S2 | [MOL File]
160141-08-2.mol | [Molecular Weight]
517.7 |
| Hazard Information | Back Directory | [Description]
L-739,750 is a peptidomimetic farnesyltransferase inhibitor (FTI). | [Uses]
L-739750 is a selective protein farnesyltransferase (PFTase) inhibitor (IC50: 0.4 nM). PFTase utilizes farnesyl diphosphate to farnesylate the cysteine residue of protein substrates having a C-terminal CAAX motif. L-739750 is a selective CAAX peptidomimetic[1][2]. | [References]
[1] 1. Kohl NE, et al. Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):9141-5. DOI:10.1073/pnas.91.19.9141
[2] Koblan KS, et al. NMR studies of novel inhibitors bound to farnesyl-protein transferase. Protein Sci. 1995 Apr;4(4):681-8. DOI:10.1002/pro.5560040408 |
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