| Identification | Back Directory | [Name]
3-[[(1S)-1-[[(5S)-5-amino-5-carboxy-pentyl]carbamoyl]-3-methyl-butyl]c arbamoyl]oxirane-2-carboxylic acid | [CAS]
160825-49-0 | [Synonyms]
AM4299 B
AM-4299 B
AM 4299 B
L-Lysine, N6-[N-[(3-carboxyoxiranyl)carbonyl]-L-leucyl]- (9CI)
3-[[(1S)-1-[[(5S)-5-amino-5-carboxy-pentyl]carbamoyl]-3-methyl-butyl]c arbamoyl]oxirane-2-carboxylic acid | [Molecular Formula]
C16H27N3O7 | [MDL Number]
MFCD00933780 | [MOL File]
160825-49-0.mol | [Molecular Weight]
373.4 |
| Hazard Information | Back Directory | [Description]
AM 4299 B is a novel thiol protease inhibitor. | [Uses]
AM4299B is an inhibitor for thiol protease. AM4299B inhibits bovine spleen cathepsin B, human kidney cathepsin L and papain with IC50s of 0.7, 0.5 and 20 μM, respectively. AM4299B can be used in research in osteoporosis, and has potential to be used as an antiparasitic agent[1]. | [IC 50]
cathepsin L: 0.5 μM (IC50); Cathepsin B: 0.7 μM (IC50) | [References]
[1] Morishita A, et al., AM4299 A and B, novel thiol protease inhibitors. J Antibiot (Tokyo). 1994 Sep;47(9):1065-8. DOI:10.7164/antibiotics.47.1065 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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