16091-26-2

4771-08-8

16091-26-2

The general procedure for the synthesis of m-aminobenzanilide from N-(3-nitrophenyl)benzamide was as follows: N-(3-nitrophenyl)benzamide (10a) was dissolved in ethanol (20 mL) and an aqueous solution of iron powder (2.5 g) and ammonium chloride (0.53 g, 10 mmol) was added. The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, it was filtered while hot, the filtrate was collected and rotary evaporated to dryness. The resulting solid was dissolved in acetone, filtered to remove insoluble matter, the filtrate was collected and rotary evaporated to dryness to give m-aminobenzanilide (11a) in 89.8% yield.