| Identification | Back Directory | [Name]
MPS1-IN-3 | [CAS]
1609584-72-6 | [Synonyms]
Mps1-IN-3
1-(4-(6-(2-(Isopropylsulfonyl)phenylamino)-9H-purin-2-ylamino)-3-methoxyphenyl)piperidin-4-ol
4-Piperidinol, 1-[3-methoxy-4-[[6-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-9H-purin-2-yl]amino]phenyl]- | [Molecular Formula]
C26H31N7O4S | [MOL File]
1609584-72-6.mol | [Molecular Weight]
537.63 |
| Chemical Properties | Back Directory | [Boiling point ]
890.3±75.0 °C(Predicted) | [density ]
1.407±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
10.35±0.10(Predicted) | [color ]
off-white | [InChIKey]
OFRMASLPWOMYHN-UHFFFAOYSA-N | [SMILES]
OC1CCN(C2=CC=C(NC3=NC(NC=N4)=C4C(NC5=C(S(=O)(C(C)C)=O)C=CC=C5)=N3)C(OC)=C2)CC1 |
| Hazard Information | Back Directory | [Uses]
Mps1-in-3 is a potent and selective Monopolar Spindle 1(MPS1) Inhibitor. | [Biological Activity]
Mps1 mediates phosphorylation of kinetochore scaffold 1.''Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1also known as TTK)a Dual-specificity kinase required for spindle pole body duplication and spindle checkpoint function. Mps1-IN-3 inhibited Mps1 kinase activity with an IC50 value of 50 nM inhibited the proliferation of U251 glioblastoma cells as determined by cell counting with an IC50 value of approximately 5 μMand sensitized glioblastoma cells to vincristine in orthotopic mouse models. | [in vivo]
Mps1-IN-3 (2 mg/kg, i.v.) sensitizes glioblastoma cells in murine tumor models, with prolonged survival and no toxicity[1]. | [IC 50]
Mps1: 50 nM (IC50) | [storage]
Store at -20°C |
|
| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
Lynnchem
|
| Telephone: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
|