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1610586-62-3

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1610586-62-3 Structure

1610586-62-3 Structure
IdentificationBack Directory
[Name]

MELK-T1(JNJ-47117096)
[CAS]

1610586-62-3
[Synonyms]

MELK-T1
JNJ-47117096
MELK-T1(JNJ-47117096)
2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide
Benzamide, 2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-
[Molecular Formula]

C21H22N4O2
[MDL Number]

MFCD28963886
[MOL File]

1610586-62-3.mol
[Molecular Weight]

362.42
Chemical PropertiesBack Directory
[Boiling point ]

558.8±50.0 °C(Predicted)
[density ]

1.250±0.06 g/cm3(Predicted)
[pka]

13.13±0.50(Predicted)
Hazard InformationBack Directory
[Uses]

JNJ-47117096 is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM[1].
[References]

[1] Johnson CN, et al. Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett. 2014 May 23;6(1):25-30. DOI:10.1021/ml5001245
[2] Beke L, et al. MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. Biosci Rep. 2015 Oct 2;35(6). pii: e00267. DOI:10.1042/BSR20150194
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