| Identification | Back Directory | [Name]
LX-2761 | [CAS]
1610954-97-6 | [Synonyms]
LX-2761
LX-2761,LX2761
LX2761; LX-2761; LX 2761;1610954-97-6
N-(1-((2-(DIMETHYLAMINO)ETHYL)AMINO)-2-METHYL-1-OXOPROPAN-2-YL)-4-(4-(2-METHYL-5-((2S,3R,4R,5S,6R)-3
Benzenebutanamide, N-[2-[[2-(dimethylamino)ethyl]amino]-1,1-dimethyl-2-oxoethyl]-4-[[2-methyl-5-[(5R)-5-C-(methylthio)-β-D-xylopyranosyl]phenyl]methyl]-
N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide | [Molecular Formula]
C32H47N3O6S | [MDL Number]
MFCD31726531 | [MOL File]
1610954-97-6.mol | [Molecular Weight]
601.8 |
| Chemical Properties | Back Directory | [Boiling point ]
843.9±65.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
12.95±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
LX2761 is chemically stable and potent inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 in vitro with IC50s of 2.2 nM and 2.7nM for hSGLT1 and hSGLT2, but displays specific SGLT1 inhibition in the gastrointestinal (GI) tract[1]. | [IC 50]
SGLT1; SGLT2 | [References]
[1] Goodwin NC, et al. Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restrictedto the Intestinal Lumen, for the Treatment of Diabetes. J Med Chem. 2017 Jan 26;60(2):710-721. DOI:10.1021/acs.jmedchem.6b01541 |
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| Company Name: |
Ontores Biotech
|
| Tel: |
0571-88760729 18072970094 |
| Website: |
www.ontoresinc.cn |
|