| Identification | Back Directory | [Name]
2-amino-6-fluoro-N-(5-fluoro-4-(4-(4-(oxetan-3-yl)piperazine-1-carbonyl)piperidin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide(WXC04788) | [CAS]
1613191-99-3 | [Synonyms]
VX-803
M-4344
ATR inhibitor 2
2-amino-6-fluoro-N-(5-fluoro-4-(4-(4-(oxetan-3-yl)piperazine-1-carbonyl)piperidin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-6-fluoro-N-[5-fluoro-4-[4-[[4-(3-oxetanyl)-1-piperazinyl]carbonyl]-1-piperidinyl]-3-pyridinyl]-
2-amino-6-fluoro-N-(5-fluoro-4-(4-(4-(oxetan-3-yl)piperazine-1-carbonyl)piperidin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide(WXC04788) | [Molecular Formula]
C25H29F2N9O3 | [MDL Number]
MFCD31803930 | [MOL File]
1613191-99-3.mol | [Molecular Weight]
541.55 |
| Hazard Information | Back Directory | [Uses]
2-Amino-6-fluoro-N-[5-fluoro-4-[4-[[4-(oxetan-3-yl)piperazin-1-yl]carbonyl]-1-piperidyl]-3-pyridyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide is an ATP-competitive and selective ATR inhibitor. Exhibits antitumor activity. Useful for monotherapy. | [in vivo]
In monotherapy efficacy studies Gartisertib shows tumor stasis to regression in tumor models with alternative lengthening of telomeres (ALT). In combination with PARP inhibitors, tumor regression could be observed in triple-negative breast cancer xenograft models[1]. | [IC 50]
ATR: <150 pM (Ki) |
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Wuxi AppTec
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022-59987777 13552403979 |
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cjbscvictory
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https://www.weikeqi-biotech.com/ |
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