| Identification | Back Directory | [Name]
ZK 200775 | [CAS]
161605-73-8 | [Synonyms]
MPQX
ZK 200775
Fanapanel
MPQX;ZK200775;ZK-200775
7-Morpholino-2,3-dioxo-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxalin-1-ylmethylphosphonic acid
[[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]phosphonicacid
[[3,4-DIHYDRO-7-(4-MORPHOLINYL)-2,3-DIOXO-6-(TRIFLUOROMETHYL)-1(2H)-QUINOXALINYL]METHYL]PHOSPHONIC ACID
P-[[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]phosphonic acid
Phosphonic acid, P-[[3,4-dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]-
[[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]-phosphonic acid hydrate | [Molecular Formula]
C14H15F3N3O6P | [MDL Number]
MFCD07364000 | [MOL File]
161605-73-8.mol | [Molecular Weight]
409.25 |
| Chemical Properties | Back Directory | [density ]
1.615±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO: ≥20mg/mL | [form ]
powder | [pka]
2.09±0.10(Predicted) | [color ]
off-white to light brown |
| Hazard Information | Back Directory | [Uses]
ZK 200775 is a competitive AMPA/kainate antagonist. Neuronal protection against cerebral ischemia. | [Biological Activity]
Competitive AMPA/kainate antagonist. In rat cortical membranes, displays high affinity for [ 3 H]-AMPA (K i = 120 nM) and [ 3 H]-CNQX (K i = 32 nM) binding sites and low affinity for kainate and NMDA channel-associated binding sites (IC 50 values range from 2.5 to 11 μ M). Inhibits currents induced by AMPA, kainate and NMDA with IC 50 values of 21 nM, 27 nM, and > 1 μ M respectively. Displays anxiolytic, anticonvulsant and muscle relaxant activity in vivo . | [storage]
Desiccate at +4°C |
|
| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|