| Identification | Back Directory | [Name]
UCB9608 | [CAS]
1616413-96-7 | [Synonyms]
UCB9608
CS-2884
UCB 9608;UCB9608
6-amino-4-{4-[(4-methoxy-2-methylphenyl)carbamyl]-2-(S)-methylpiperazin-1-yl}-1-methylpyrazolo[3,4-d]pyrimidine
(3S)-4-(6-Amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methyl-1-piperazinecarboxamide
1-Piperazinecarboxamide, 4-(6-amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methyl-, (3S)- | [Molecular Formula]
C20H26N8O2 | [MDL Number]
MFCD31813684 | [MOL File]
1616413-96-7.mol | [Molecular Weight]
410.47 |
| Chemical Properties | Back Directory | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.36±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
WRONAJQPZWDYAR-ZDUSSCGKSA-N | [SMILES]
N1(C(NC2=CC=C(OC)C=C2C)=O)CCN(C2N=C(N)N=C3N(C)N=CC3=2)[C@@H](C)C1 |
| Hazard Information | Back Directory | [Uses]
UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent[1]. | [References]
[1] Reuberson J, et al. Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo. J Med Chem. 2018 Aug 9;61(15):6705-6723. DOI:10.1021/acs.jmedchem.8b00521 |
|
|