| Identification | Back Directory | [Name]
1H-Indazole-5-carboxamide, N-(3,4-dichlorophenyl)-1-methyl- | [CAS]
1619884-67-1 | [Synonyms]
PSB1491
PSB-1491
PSB 1491
1H-Indazole-5-carboxamide, N-(3,4-dichlorophenyl)-1-methyl-
N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide (NTZ-1091) | [Molecular Formula]
C15H11Cl2N3O | [MDL Number]
MFCD31629806 | [MOL File]
1619884-67-1.mol | [Molecular Weight]
320.17 |
| Hazard Information | Back Directory | [Description]
PSB-1491 is a potent, selective, competitive, and reversible inhibitor of monoamine oxidase B (MAO-B). | [Uses]
PSB-1491 is a selective and competitive monoamine oxidase B (MAO-B) inhibitor with an IC50 of 0.386 nM for hMAO-B. PSB-1491 shows >25000-fold selective versus MAO-A[1]. | [IC 50]
hMAO-B: 0.0386 nM (IC50) | [References]
[1] Tzvetkov NT, et al. Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency. J Med Chem. 2014 Aug 14;57(15):6679-703. DOI:10.1021/jm500729a |
|
|