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AZD1208 hydrochloride is an orally bioavailable, highly selective PIM kinases inhibitor[1]. | [IC 50]
PIM2 | [References]
[1] Dakin LA, et al. Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4599-604. DOI:10.1016/j.bmcl.2012.05.098
[2] Kreuz S, et al. Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas. Mol Cancer. 2015 Dec 8;14:205. DOI:10.1186/s12943-015-0477-z
[3] Harada M, et al. The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. Oncotarget. 2015 Nov 10;6(35):37930-47. DOI:10.18632/oncotarget.6122 |
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