| Hazard Information | Back Directory | [Description]
JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in Tau-overexpressing HeLa cells, endogenous Tau in neuroblastoma cells, and endogenous Tau in primary neurons from rTg4510 mice, a mouse model of Alzheimer’s disease | [Uses]
JG-48 is a Hsp70 inhibitor that can reduce tau levels in models of tauopathy[1]. | [References]
[1] Young ZT, et al. Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy. Cell Chem Biol. 2016 Aug 18;23(8):992-1001. DOI:10.1016/j.chembiol.2016.04.014 |
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