| Chemical Properties | Back Directory | [Boiling point ]
549.9±60.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 25 mg/ml) | [form ]
solid | [pka]
-1.84±0.20(Predicted) | [color ]
Pale yellow | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | [InChIKey]
XJBQRMOGMULGPP-PDGQHHTCSA-N | [SMILES]
O=C1N2C(SCCC2)=N/C1=C\C3=CC(OCC4=CC=C(C=C4)Cl)=CC=C3 |
| Hazard Information | Back Directory | [Description]
PSB-CB5 (1627710-30-8) is a potent and selective GPR18 antagonist (IC50?= 0.279 μM) exhibiting >36-fold selectivity against GPR55 and CB1 and 14-fold selectivity against CB2.1? Inhibits N-arachidonylglycine-induced acrosomal exocytosis in human spermatozoa indicating that GPR18 may be involved in physiological processes of human spermatozoa.2 | [Uses]
PSB-CB5 is a potent and selective antagonist of GRP18. PSB-CB5 has the potential for the research of metabolic disease and obesity[1]. | [storage]
Store at -20°C | [References]
1) Rempel?et al. (2014),?Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55; Med. Chem. Comm., 5?632
2) Flegel?et al.?(2016),?Characterization of Non-Olfactory GPCRs in Human Sperm With a Focus on GPR18; Sci. Rep.,?6?32255 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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