| Identification | Back Directory | [Name]
Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]- | [CAS]
1627900-92-8 | [Synonyms]
P2X7 receptor antagonist-3
Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]- | [Molecular Formula]
C17H12ClF3N6O | [MOL File]
1627900-92-8.mol | [Molecular Weight]
408.77 |
| Hazard Information | Back Directory | [Uses]
P2X7 receptor antagonist-3 is a potent P2X7 receptor antagonist with P2X7R IC50 values of 4.2 nM in humans and 6.8 nM in rats[1]. | [IC 50]
hP2X7R: 4.2 nM (IC50); rP2X7R: 6.8 nM (IC50) | [References]
[1] Brad M Savall, et al. Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists. ACS Med Chem Lett. 2015 Apr 24;6(6):671-6. DOI:10.1021/acsmedchemlett.5b00089 |
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