| Identification | Back Directory | [Name]
3-[(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)form
amido]propanoic acid | [CAS]
16296-42-7 | [Synonyms]
3-[(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)form
amido]propanoic acid | [Molecular Formula]
C8H9N3O5 | [MDL Number]
MFCD09938887 | [MOL File]
16296-42-7.mol | [Molecular Weight]
227.18 |
| Hazard Information | Back Directory | [Uses]
DB28 is a novel MR1 ligand. DB28 decreases cell surface expression of MR1 and competitively inhibits activation of MAIT cells by agonist ligands[1]. | [Definition]
ChEBI: N-[(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)carbonyl]-beta-alanine is a beta-alanine derivative obtained by formal condensation of the carboxy group of orotic acid with the amino group of beta-alanine. One of a series of mucosal-associated invariant T (MAIT) cell agonists. It has a role as a MAIT cell agonist. It is functionally related to an orotic acid. | [References]
[1] Alexandra J Corbett, et al. Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries. Front Immunol. 2020 Aug 27:11:1961. DOI:10.3389/fimmu.2020.01961 |
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Biorbyt Ltd.
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