| Identification | Back Directory | [Name]
Protein degrader 1 (TFA) | [CAS]
1631137-51-3 | [Synonyms]
S)-AHPC TFA
VH032-NH2 TFA
(S,R,S)-AHPC TFA
E3 ligase Ligand 6
VHL ligand 1 (TFA)
Protein degrader 1 (TFA)
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate | [Molecular Formula]
C24H31F3N4O5S | [MDL Number]
MFCD31630810 | [MOL File]
1631137-51-3.mol | [Molecular Weight]
544.59 |
| Hazard Information | Back Directory | [Description]
VHL-7526, also known as Protein degrader 1, is a protein degrader and is a small molecule ligand for VHL | [Uses]
(S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1]. | [IC 50]
VHL | [References]
[1] Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. DOI:10.1021/acschembio.5b00442 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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