| Identification | Back Directory | [Name]
PROTAC FLT-3 degrader 1 | [CAS]
2230826-81-8 | [Synonyms]
PROTAC FLT-3 degrader 1
PROTACFLT-3degrader1/FLT3PROTAC | [Molecular Formula]
C52H61N9O9S2 | [MDL Number]
MFCD32705099 | [MOL File]
2230826-81-8.mol | [Molecular Weight]
1020.23 |
| Chemical Properties | Back Directory | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 150 mg/mL (147.03 mM; Need ultrasonic) | [form ]
Solid | [pka]
12.59±0.70(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
PROTAC FLT-3 degrader 1 is a von Hippel-Lindau-based PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction[1]. | [References]
[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432. |
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