| Identification | Back Directory | [Name]
Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)- | [CAS]
1631164-25-4 | [Synonyms]
(R)-N-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)-2-cyclopropyl-1-((4-fluorophenyl)sulfonyl)-
(2R)-N-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-carboxamide 1',1'-dioxide
Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2R)- | [Molecular Formula]
C29H26ClF4N3O5S2 | [MOL File]
1631164-25-4.mol | [Molecular Weight]
672.11 |
| Chemical Properties | Back Directory | [density ]
1.60±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
12.47±0.40(Predicted) | [color ]
white to beige | [Optical Rotation]
[α]/D 105 to 125°, c =0.5 in chloroform-d | [InChIKey]
PZGSYNNVPNLHQG-AREMUKBSSA-N | [SMILES]
O=C(C1=CC2=C(N(S(=O)(C3=CC=C(F)C=C3)=O)[C@H](C4CC4)C2(CC5)CCS5(=O)=O)C=C1)NCC6=NC=C(C(F)(F)F)C=C6Cl |
| Hazard Information | Back Directory | [Uses]
BAY 1214784 is a potent, selective, and orally active antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R). BAY 1214784 is a spiroindoline derivative compound. BAY 1214784 effectively lowers plasma luteinizing hormone levels by up to 49%, at the same time being associated with low pharmacokinetic variability and good tolerability. BAY 1214784 has the potential for the research of uterine fibroids[1]. | [Biological Activity]
BAY-786 is a negative control for an orally availablenon-toxicpotentand selective GnRH-R antagonist BAY-784. | [References]
[1] Panknin O, et al. Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenop DOI:10.1021/acs.jmedchem.0c01076 |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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