| Identification | Back Directory | [Name]
2-AMINO-5-BROMOBENZAMIDE | [CAS]
16313-66-9 | [Synonyms]
5-bromoanthranilamide
5-Methoxy-phthalicacid
2-AMINO-5-BROMOBENZAMIDE
Benzamide, 2-amino-5-bromo-
2-Amino-5-bromobenzamide ,97%
Morphinan-3,14-diol,4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-,(5α,6α)-,ethanedioate(1:6)(salt) | [EINECS(EC#)]
200-589-5 | [Molecular Formula]
C7H7BrN2O | [MDL Number]
MFCD04037881 | [MOL File]
16313-66-9.mol | [Molecular Weight]
215.05 |
| Chemical Properties | Back Directory | [Melting point ]
189-191℃ (water ethanol ) | [Boiling point ]
291.2±25.0℃ (760 Torr) | [density ]
1.698±0.06 g/cm3 (20 ºC 760 Torr) | [Fp ]
129.9±23.2℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
15.15±0.50(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white to light yellow solid | [Synthesis]
The general procedure for the synthesis of 2-amino-5-bromobenzamide from benzimidic acid,2-amino- (9CI) was as follows: 2-aminobenzamide (1.00 g, 7.34 mmol) was dissolved in acetonitrile (20 mL) at room temperature and N-bromosuccinimide (1.36 g, 7.70 mmol) was added with stirring. The reaction mixture was stirred continuously at room temperature for 0.5 h. The reaction was subsequently quenched with ice-cold water. The resulting precipitate was collected by filtration and the residue was recrystallized with acetonitrile to afford the light yellow solid product 2-amino-5-bromobenzamide (1.47 g, 93% yield) with a melting point of 186-187 °C (literature value: 185-187 °C, 27 °C). | [References]
[1] Tetrahedron, 2016, vol. 72, # 1, p. 123 - 133
[2] Tetrahedron Letters, 2006, vol. 47, # 23, p. 3889 - 3892
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 4040 - 4043
[4] Archiv der Pharmazie, 1981, vol. 314, # 2, p. 176 - 180
[5] Molecules, 2017, vol. 22, # 1, |
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