| Identification | Back Directory | [Name]
Mavoglurant (racemate) | [CAS]
1636881-61-2 | [Synonyms]
AFQ-056 racemate
Mavoglurant (racemate)
1H-Indole-1-carboxylic acid, octahydro-4-hydroxy-4-[2-(3-methylphenyl)ethynyl]-, methyl ester, (3aR,4S,7aR)-rel- | [Molecular Formula]
C19H23NO3 | [MDL Number]
MFCD30534423 | [MOL File]
1636881-61-2.mol | [Molecular Weight]
313.39 |
| Chemical Properties | Back Directory | [Boiling point ]
476.3±45.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (159.55 mM) | [form ]
Solid | [pka]
12.75±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Mavoglurant racemate (AFQ-056 racemate) is the racemate of Mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist[1]. Mavoglurant (racemate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
mGluR5 | [References]
[1] Vranesic I, et al. AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: identification, SAR and pharmacological characterization. Bioorg Med Chem. 2014 Nov 1;22(21):5790-80 DOI:10.1016/j.bmc.2014.09.033 |
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Musechem
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www.musechem.com |
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MedChemExpress
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www.medchemexpress.com |
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