| Hazard Information | Back Directory | [Description]
SZV558 is a potent inhibitor of both rodent and human MAO-B, proved to be safe in high doses with no hERG and mutagenic activities and demonstrated neuroprotection in an in vivo chronic model of PD. | [Uses]
SZV-558 is a potent and selective MAO-B inhibitor with IC50 values of 50 and 60 nM for rats and humans, respectively. SZV-558 can be used in studies of Parkinson's disease (PD) models[1]. | [IC 50]
rMAO-B: 50 nM (IC50); hMAO-B: 60 nM (IC50) | [References]
[1] Baranyi M, et al. Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson's disease. Mol Neurodegener. 2016 Jan 13;11:6. DOI:10.1186/s13024-015-0067-y |
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