| Chemical Properties | Back Directory | [Boiling point ]
574.8±60.0 °C(Predicted) | [density ]
1.343±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 11mg/mL,DMF:PBS (pH 7.2) (1:2): 0.3mg/mL,DMSO: 10mg/mL | [form ]
A crystalline solid | [pka]
15.67±0.30(Predicted) |
| Hazard Information | Back Directory | [Uses]
Antibacterial agent 219 (Compound 2/75c) exhibits antibacterial activity by targeting cell wall biosynthesis. Antibacterial agent 219 inhibits methicillin-resistant Staphylococcus aureus (MRSA) strains (MIC=0.5-32 μg/mL), Enterococcus faecium (MIC=2 μg/mL) and S. aureus (MIC=2 μg/mL)[1][2]. | [Biological Activity]
CAY10742 is an orally bioavailable oxadiazole antibiotic.1 It is active against the Gram-positive bacteria S. aureus, S. epidermidis, S. haemolyticus, B. cereus, B. licheniformis, E. faecalis, and E. faecium (MICs = 1-4 μg/ml), including laboratory strains and clinical isolates with varying degrees of resistance to methicillin, vancomycin, linezolid, and other antibiotics. CAY10742 (40 mg/kg) reduces the number of bacteria in mouse neutropenic thigh models of linezolid-sensitive or -resistant methicillin-resistant S. aureus (MRSA) infection. | [References]
1.Boudreau, M.A., Ding, D., Meisel, J.E., et al.Structure-activity relationship for the oxadiazole class of antibacterialsMed. Chem. Lett.11(3)322-326(2019)
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