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1651890-44-6

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1651890-44-6 Structure

1651890-44-6 Structure
IdentificationBack Directory
[Name]

Pyridoclax
[CAS]

1651890-44-6
[Synonyms]

MR 29072
Pyridoclax
MR-29072;MR 29072
Pyridoclax(MR29072)
Pyridoclax (Synonyms: MR-29072)
5,6'-Di(pyridin-5-yl)-5'-methyl-3-((E)-2-phenylethenyl)-2,3'-bipyridine
3'-Methyl-3''-[(1E)-2-phenylethenyl]-3,2':5',2'':5'',3'''-quaterpyridine
[EINECS(EC#)]

604-604-1
[Molecular Formula]

C29H22N4
[MOL File]

1651890-44-6.mol
[Molecular Weight]

426.51
Chemical PropertiesBack Directory
[Boiling point ]

663.6±55.0 °C(Predicted)
[density ]

1.192±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

3.65±0.12(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Pyridoclax is a potential Mcl-1 inhibitor.
[IC 50]

Mcl-1
[References]

[1] Gloaguen C, et al. First evidence that oligopyridines, α-helix foldamers, inhibit Mcl-1 and sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies. J Med Chem. 2015 Feb 26;58(4):1644-68. DOI:10.1021/jm500672y
[2] Groo AC, et al. Comparison of 2 strategies to enhance Pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis. Eur J Pharm Sci. 2017 Jan 15;97:218-226. DOI:10.1016/j.ejps.2016.11.025
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