| Chemical Properties | Back Directory | [Boiling point ]
792.7±60.0 °C(Predicted) | [density ]
1.201±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.11±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
SCO-267 is a novel GPR40 full agonist, improving liver parameters in a mouse model of nonalcoholic fatty liver disease without affecting glucose or body weight. | [Uses]
SCO-267 is an allosteric GPR40 full agonist. SCO-267 can be used for the research of chronic diseases including diabetes[1]. | [in vivo]
SCO-267 (1 or 10 mg/kg; p.o.) improves insulin sensitivity and exerts sustained glucose-lowering effect[1]. | Animal Model: | N-STZ rats[1] | | Dosage: | 1 or 10 mg/kg | | Administration: | P.o.; | | Result: | Improved insulin sensitivity and exerted sustained glucose-lowering effect.
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| [References]
[1] Koyama R, et al. Chronic Exposure to SCO-267, an Allosteric GPR40 Full Agonist, Is Effective in Improving Glycemic Control in Rats. Mol Pharmacol. 2021 Apr;99(4):286-293. DOI:10.1124/molpharm.120.000168 |
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| Company Name: |
Unibest Pharmaceutical Technology Co., Ltd.
|
| Tel: |
13735578103 |
| Website: |
isite.baidu.com/site/wjzvpc43/3e462afc-f1d0-46aa-b5b6-46dbd294d89e?fid=nhf1pjcdpjcznhcvn1cyrhcdn1-xnwcdg1d&ch=4&bd_vid=nhf1pjcdpjcznhcvn1cyrhcdn1-xnwcdg17xnh0sg1wxp1b1pjr1pjczp1b&ch=4&bd_bxst= |
| Company Name: |
commedx
|
| Tel: |
010-46598925 18519000250 |
| Website: |
http://www.commedx.com |
|