| Identification | Back Directory | [Name]
Rodatristat) | [CAS]
1673571-51-1 | [Synonyms]
Rodatristat)
Rodatristat ethyl
KAR-5585
(KAR5585
2,8-Diazaspiro[4.5]decane-3-carboxylic acid, 8-[2-amino-6-[(1R)-1-(5-chloro[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, ethyl ester, (3S)- | [Molecular Formula]
C29H31ClF3N5O3 | [MDL Number]
MFCD32215291 | [MOL File]
1673571-51-1.mol | [Molecular Weight]
590.04 |
| Hazard Information | Back Directory | [Uses]
Rodatristat is used in the method for treating interstitial lung disease using a tryptophan hydroxylase inhibitor. | [in vivo]
Rodatristat ethyl (100 or 200 mg/kg; oral administration; once daily; for 28 days; male Sprague-Dawley rats) treatment decreases erum, gut and lung 5-HT levels in a dose-dependent manner and significantly reduces pulmonary arterial pressure, and pulmonary vessel wall thickness and occlusion in male rats with monocrotaline (MCT)[1]. | Animal Model: | Male Sprague-Dawley rats (175-200 g)[1] | | Dosage: | 100 mg/kg or 200 mg/kg | | Administration: |
Oral administration; once daily; for 28 days | | Result: | Decreased serum, gut and lung 5-HT levels in a dose-dependent manner and significantly reduced pulmonary arterial pressure, and pulmonary vessel wall thickness and occlusion in male rats.
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| [IC 50]
5-HT1 Receptor; TPH1 | [storage]
Store at -20°C |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
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