| Identification | Back Directory | [Name]
4-Bromoindole-2-carboxylic acid methyl ester | [CAS]
167479-13-2 | [Synonyms]
Methyl 4-bromoindole-2-carboxylate
Methyl 4-bromo-1H-indole-2-carboxylate 98%
4-Bromoindole-2-carboxylic acid methyl ester
4-bromo-1H-indole-2-carboxylic acid methyl ester
1H-Indole-2-carboxylic acid, 4-broMo-, Methyl ester | [Molecular Formula]
C10H8BrNO2 | [MDL Number]
MFCD04966956 | [MOL File]
167479-13-2.mol | [Molecular Weight]
254.08 |
| Chemical Properties | Back Directory | [Boiling point ]
386.2±22.0 °C(Predicted) | [density ]
1.629±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
solid | [pka]
14.04±0.30(Predicted) | [color ]
Beige |
| Hazard Information | Back Directory | [Synthesis]
GENERAL METHOD: Methyl 3-aryl-2-azidoacrylate (20.0 mmol) was added in a single addition to a pre-heated to reflux xylene solution (75 mL) and the reaction was kept at reflux for 2 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator. The resulting residue was purified by silica gel column chromatography with mixed petroleum ether/ethyl acetate solvent as eluent. The synthesis of compounds 12, 18 and 19 has been reported in the literature [9b, 13, 14]. | [References]
[1] European Journal of Medicinal Chemistry, 2012, vol. 49, p. 379 - 396 |
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