| Identification | Back Directory | [Name]
4-BROMOOXINDOLE | [CAS]
99365-48-7 | [Synonyms]
4-BROMOOXINDOLE
4-Bromo-2-oxindole
4-BROMO-2-OXYINDOLE
4-Bromoindolin-2-one
4-Bromooxindole ,98%
4-broMo-1H-indol-1-ol
4-bromo-2H-indol-2-one
4-BroMo-1,3-dihydro-indol-2-one
4-Bromo-2,3-dihydro-1H-indol-2-one
4-Bromo-1,3-dihydro-2H-indol-2-one
4-BROMOOXINDOLE in stock Factory
2H-Indol-2-one, 4-broMo-1,3-dihydro-
4-BroMo-2,3-dihydro-1H-indol-2-one, 97%+ | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C8H6BrNO | [MDL Number]
MFCD06659911 | [MOL File]
99365-48-7.mol | [Molecular Weight]
212.04 |
| Chemical Properties | Back Directory | [Melting point ]
202-208 | [Boiling point ]
358.2±42.0 °C(Predicted) | [density ]
1.666±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder to crystal | [pka]
13.24±0.20(Predicted) | [color ]
White to Light yellow to Light orange | [InChI]
InChI=1S/C8H6BrNO/c9-6-2-1-3-7-5(6)4-8(11)10-7/h1-3H,4H2,(H,10,11) | [InChIKey]
XQQPPAZTHUEMPF-UHFFFAOYSA-N | [SMILES]
N1C2=C(C(Br)=CC=C2)CC1=O | [CAS DataBase Reference]
99365-48-7 |
| Hazard Information | Back Directory | [Uses]
4-Bromooxindole is a reactant that has been used in the preparation of benzylidene bromo isatin derivatives with antitumor activity. | [Synthesis]
To a stirred solution of 2-(2-bromo-6-nitrophenyl)acetic acid (0.66 g, 2.54 mmol) dissolved in a solvent mixture of 50% H2SO4 (6.0 mL) and EtOH (10.0 mL), zinc powder (0.66 g, 10.1 mmol) was added, and the reaction was carried out at 90 °C in an N2 atmosphere. After completion of the reaction, the reaction mixture was treated according to a similar method as in preparation 5 to give the intermediate 4-bromoindolone (0.50 g, 93% yield). The mass spectrum (electrospray ionization) showed an M+1 peak of 212 and an M+2 peak of 214. | [References]
[1] Patent: US2003/225127, 2003, A1. Location in patent: Page 16
[2] Chemical and Pharmaceutical Bulletin, 1985, vol. 33, # 4, p. 1414 - 1418 |
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