| Identification | Back Directory | [Name]
3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine | [CAS]
1679330-37-0 | [Synonyms]
AZ Dyrk1B 33
3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
1H-Pyrrolo[2,3-c]pyridine, 3-(2-methyl-4-pyrimidinyl)-1-(phenylmethyl)- | [Molecular Formula]
C19H16N4 | [MDL Number]
MFCD30720886 | [MOL File]
1679330-37-0.mol | [Molecular Weight]
300.36 |
| Chemical Properties | Back Directory | [Boiling point ]
541.2±50.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
6.79±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
4,6-Bis(4-fluorophenyl)-2-methyl-5-(4-pyridyl)-2H-pyrazolo[3,4-b]pyridine is a potential Dyrk1B kinase inhibitor and used to investigate resistance mechanism related to stress response in cells. | [Biological Activity]
Potent and selective Dyrk1B kinase inhibitor th at increased the number of incretin-expressing cells in diabetic mice.
AZ Dyrk1B 33 is a potent and selective Dyrk1B kinase (dual-specificity tyrosine phosphorylation-regulated kinase 1B) inhibitor. AZ Dyrk1B 33 potently increases the numbers of neurogenin 3-expressing enteroendocrine progenitorsGip-expressing K-cellsand Glp-1-expressing L-cells in zebrafish and diabetic mice. It decreases glucose levels in both larval and juvenile zebrafish. | [IC 50]
DYRK1B | [storage]
Store at -20°C |
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