| Identification | Back Directory | [Name]
BMT-124110 | [CAS]
1679371-59-5 | [Synonyms]
BMT-124110
BMT 124110,BMT124110
BMT-124110, 10 mM in DMSO
Acetamide, N-[8-[[(2S)-2-amino-2,4-dimethylpentyl]oxy]-5H-[1]benzopyrano[3,4-c]pyridin-2-yl]- | [Molecular Formula]
C21H27N3O3 | [MDL Number]
MFCD34469994 | [MOL File]
1679371-59-5.mol | [Molecular Weight]
369.46 |
| Chemical Properties | Back Directory | [Boiling point ]
610.4±55.0 °C(Predicted) | [density ]
1.189±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.36±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively[1]. | [in vivo]
BMT-124110 is added directly onto the spinal corevd by microiontophoresis, leading to reduction in windup-induced activity in 10 of 14 animals[1]. | [References]
[1] Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86. DOI:10.1124/jpet.116.235333 |
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