| Identification | Back Directory | [Name]
CC-618 | [CAS]
1680204-90-3 | [Synonyms]
CC-618
5-Thiazolecarboxamide, 4-methyl-2-[4-(trifluoromethyl)phenyl]-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]- | [Molecular Formula]
C20H15F6N3O3S2 | [MOL File]
1680204-90-3.mol | [Molecular Weight]
523.47 |
| Hazard Information | Back Directory | [Description]
CC618 is a potent and selective PPARβ/δ antagonist. CC618 selectively antagonizes agonist-induced PPARβ/δ activity with an IC50 = 10.0 μM. The treatment of PPARβ/δ with CC618 leads to a covalent modification of Cys249, located centrally in the PPARβ/δ ligand binding pocket, corresponding to the conversion of its thiol moiety to a 5-trifluoromethyl-2-pyridylthioether. | [Uses]
CC618 is a selective peroxisome proliferator-activated receptor (PPARβ/δ) antagonist that exhibits antagonism by covalently binding to PPARβ/δ receptors[1]. | [References]
[1] Kaupang ?, et al. Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618. Eur J Med Chem. 2015 Apr 13;94:229-36. DOI:10.1016/j.ejmech.2015.03.006 |
|
|