1680204-90-3
1680204-90-3 结构式
基本信息
中文别名
化合物CC618化合物CC618,10 MM DMSO 溶液
4-甲基-2-[4-(三氟甲基)苯基]-N-[2-[[5-(三氟甲基)-2-吡啶基]磺酰基]乙基]乙基]-5-噻唑烷酰胺
英文别名
CC-6185-Thiazolecarboxamide, 4-methyl-2-[4-(trifluoromethyl)phenyl]-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-
应用领域
用途一
CC618 is a potent and selective PPARβ/δ antagonist. CC618 selectively antagonizes agonist-induced PPARβ/δ activity with an IC50 = 10.0 μM. The treatment of PPARβ/δ with CC618 leads to a covalent modification of Cys249, located centrally in the PPARβ/δ ligand binding pocket, corresponding to the conversion of its thiol moiety to a 5-trifluoromethyl-2-pyridylthioether.