| Identification | Back Directory | [Name]
Acetyl-Tau Peptide (273-284) amide | [CAS]
1684399-52-7 | [Synonyms]
Acetyl-Tau Peptide (273-284) amide
L-Leucinamide, N-acetylglycyl-L-lysyl-L-valyl-L-glutaminyl-L-isoleucyl-L-isoleucyl-L-asparaginyl-L-lysyl-L-lysyl-L-leucyl-L-α-aspartyl- | [Molecular Formula]
C64H116N18O17 | [MOL File]
1684399-52-7.mol | [Molecular Weight]
1409.74 |
| Chemical Properties | Back Directory | [Boiling point ]
1733.8±65.0 °C(Predicted) | [density ]
1.204±0.06 g/cm3(Predicted) | [pka]
4.20±0.10(Predicted) | [Sequence]
Ac-Gly-Lys-Val-Gln-Ile-Ile-Asn-Lys-Lys-Leu-Asp-Leu-NH2 |
| Hazard Information | Back Directory | [Uses]
Acetyl-Tau Peptide (273-284) amide is an acetylated Tau peptide fragment. Acetyl-Tau Peptide (273-284) amide limits the substantial aggregation of Ac-Aβ(25–35)-NH2 and can be used as an inhibitor of Ac-Aβ(25–35)-NH2. Acetyl-Tau Peptide (273-284) amide can be used as an experimental model to investigate the Aβ/Tau cross-interaction [1][2]. | [References]
[1] Di Natale G, et al. Aβ and Tau Interact with Metal Ions, Lipid Membranes and Peptide-Based Amyloid Inhibitors: Are These Common Features Relevant in Alzheimer's Disease? Molecules. 2022 Aug 9;27(16):5066. DOI:10.3390/molecules27165066
[2] Do TD, et al. Interactions between amyloid-β and Tau fragments promote aberrant aggregates: implications for amyloid toxicity. J Phys Chem B. 2014 Sep 25;118(38):11220-30. DOI:10.1021/jp506258g |
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