| Identification | Back Directory | [Name]
FRIEDELAN-3BETA-OL | [CAS]
16844-71-6 | [Synonyms]
Epifriedelal
Epifriedelinol
Epifriedelanol
Friedelin-3β-ol
3-Epifriedelinol
FRIEDELAN-3BETA-OL
LONGAN TRITERPANE A
3beta-Hydroxyfriedelane
24,25,26-Trinoroleanan-3-ol,5,9,13-trimethyl-, (3b,4b,5b,8a,9b,10a,13a,14b)-
(3S,4R,4aS,6aS,6aS,6bR,8aR,12aR,14aS,14bS)-4,4a,6a,6b,8a,11,11,14a-octamethyl-1,2,3,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-hexadecahydropicen-3-ol | [Molecular Formula]
C30H52O | [MDL Number]
MFCD04039822 | [MOL File]
16844-71-6.mol | [Molecular Weight]
428.73 |
| Chemical Properties | Back Directory | [Melting point ]
279-283 °C(Solv: chloroform (67-66-3)) | [Boiling point ]
478.3±13.0 °C(Predicted) | [density ]
0.966±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
15.18±0.70(Predicted) | [color ]
Off-White | [LogP]
11.450 (est) |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. Derived from Aster tataricus LF. | [Uses]
Epifriedelanol is a triterpenoid compound with antiproliferative and anti-cancer agent. | [Definition]
ChEBI: Epi-Friedelanol is a triterpenoid. | [in vivo]
Epifriedelanol (5-10 mg/kg; p.o.; 21 d) can against Bisphenol A (BPA) (HY-18260)-induced gonadotoxicity and has anti-inflammatory effects[3].
| Animal Model: | Male Sprague-Dawley rats, (180-200 g, age of 9-10 weeks)[3] | | Dosage: | 5, 10 mg/kg | | Administration: | Oral gavage (p.o.); 21 days | | Result: | Showed a substantial decrease in prostate weight treated with Bisphenol A (BPA) (HY-18260), which could increase prostate size.
Did not exhibit any detectable alterations in hematologic parameters when compared to the control group, supporting its biosafety and application in in vivo systems.
Was preemptive against BPA-induced toxicity at both its high (10 mg/kg) and low (5 mg/kg) doses.
Effectively retained physiological serum estradiol concentrations in a dose-dependent manner.
Reduced peroxidation, and suppression of inflammatory markers (NO, IL-6 and TNF-α), indicating substantial antiinflammatory potential.
|
|
|
|